超碰97自拍_久久99久久98精品免观看软件_在线亚洲一区_九九视频这里只有精品_国产精品一区二区欧美视频_精品国产区一区

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質(zhì)量反饋  關于我們  聯(lián)系我們
午夜少妇性开放影院,欧美激情一区二区三区成人,四虎永久在线精品国产馆v视影院
首頁 > 產(chǎn)品中心 > 標記一抗 > 產(chǎn)品信息
Rabbit Anti-NCBP2/PE Conjugated antibody (bs-19044R-PE)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-19044R-PE
英文名稱 Rabbit Anti-NCBP2/PE Conjugated antibody
中文名稱 PE標記的核帽結合蛋白2抗體
別    名 20 kDa nuclear cap binding protein; CBC2; CBP20; Cell proliferation inducing gene 55 protein; NCBP 2; NCBP2_HUMAN; NCBP 20 kDa subunit; NCBP interacting protein 1; NIP1; Nuclear cap binding protein subunit 2; PIG55.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  結合蛋白  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, )
產(chǎn)品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 18kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human NCBP2
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The product of this gene is a component of the nuclear cap-binding protein complex (CBC), which binds to the monomethylated 5' cap of nascent pre-mRNA in the nucleoplasm. The encoded protein has an RNP domain commonly found in RNA binding proteins, and contains the cap-binding activity. The CBC promotes pre-mRNA splicing, 3'-end processing, RNA nuclear export, and nonsense-mediated mRNA decay. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Function:
Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus via its interaction with ALYREF/THOC4/ALY, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC) via its interaction with UPF1, promoting the interaction between UPF1 and UPF2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with SRRT/ARS2, thereby being required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of PARN, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, NCBP2/CBP20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires NCBP1/CBP80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure.

Subunit:
Component of the nuclear cap-binding complex (CBC), a heterodimer composed of NCBP1/CBP80 and NCBP2/CBP20 that interacts with m7GpppG-capped RNA. Found in a U snRNA export complex with RNUXA/PHAX, NCBP1/CBP80, NCBP2/CBP20, RAN, XPO1 and m7G-capped RNA. Interacts with RNUXA/PHAX, EIF4G1, HNRNPF, HNRNPH1 and ALYREF/THOC4/ALY.

Subcellular Location:
Nucleus. Cytoplasm

Similarity:
Belongs to the RRM NCBP2 family.
Contains 1 RRM (RNA recognition motif) domain.

Database links:

Entrez Gene: 22916 Human

Entrez Gene: 68092 Mouse

Omim: 605133 Human

SwissProt: P52298 Human

SwissProt: Q9CQ49 Mouse

Unigene: 591671 Human

Entrez Gene: 22916 Human

Entrez Gene: 68092 Mouse

Omim: 605133 Human

SwissProt: P52298 Human

SwissProt: Q9CQ49 Mouse

Unigene: 591671 Human

 



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.ggggww.cn 北京博奧森生物技術有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
主站蜘蛛池模板: 国产在线播放观看 | 一边摸一边桶一边脱免费视频 | 手机午夜福利1000视频 | 欧美精品久久一区二区 | 国产精品视频免费网站 | 日本三线免费视频观看 | 亚洲二区中文字幕 | 国产亚洲在 | 嫩草午夜 | 亚洲热妇无码播放aV另类 | 国产v无毛 | 欧美一级淫片aaaa | 欧美无毛视频 | 少妇做爰免费视频网站裸体艺术 | 国产无遮挡又黄又爽动态图 | 99久久久久久中文字幕一区 | 第一次破處在线国语视频播放 | 国产乱人伦偷精品视频 | 亚洲啊v在线观看 | 久久不见久久见免费影院视频观看 | 亚洲精品一卡二卡三卡四卡2021 | 日本高清无卡码一区二区久久 | 国产色诱视频在线播放网站 | 国产在线导航 | 一本久道中文字幕精品亚洲嫩 | 啊灬啊灬轻点第一次和外国人 | 国产午夜精品一区 | chinese国产一区二区 | 啊v在线看 | 国产精品99精品无码视亚 | 久久国产精品嫩草影院的推荐理由 | 日本a级影片 | 蜜臀av性色av | 国产精品99久久久久久宅男 | 亚洲热妇无码播放aV另类 | 特黄AAAAAAA片免费视频 | 狠狠躁夜夜躁久久躁别揉 | 日韩卡一卡二无线乱码新区仙踪林 | 日本黄色片一级片 | 国产午夜成人久久无码一区二区 | 干干人人 |