超碰97自拍_久久99久久98精品免观看软件_在线亚洲一区_九九视频这里只有精品_国产精品一区二区欧美视频_精品国产区一区

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
99视频精品全部在线观看,99久久婷婷国产综合精品免费,国产精品影院在线观看
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-NFIP1/BF594 Conjugated antibody (bs-19058R-BF594)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-19058R-BF594
英文名稱 Rabbit Anti-NFIP1/BF594 Conjugated antibody
中文名稱 BF594標記的乳腺癌相關蛋白SGA 1M抗體
別    名 0610010M22Rik; Breast cancer associated protein SGA 1M; Breast cancer-associated protein SGA-1M; MGC10924; N4WBP5; Ndfip1; Nedd4 family interacting protein 1; NEDD4 family-interacting protein 1; NEDD4 WW domain binding protein 5; NEDD4 WW domain-binding protein 5; NFIP1_HUMAN; Putative MAPK activating protein PM13; Putative MAPK-activating protein PM13; Putative NF kappa B activating protein 164; Putative NF-kappa-B-activating protein 164; Putative NFKB and MAPK activating protein; Putative NFKB and MAPK-activating protein.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  細胞生物  表觀遺傳學  泛素  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse,  (predicted: Rat, Chicken, Pig, Cow, Horse, Rabbit, Sheep, )
產品應用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 25kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human NFIP1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
The protein encoded by this gene belongs to a small group of evolutionarily conserved proteins with three transmembrane domains. It is a potential target for ubiquitination by the Nedd4 family of proteins. This protein is thought to be part of a family of integral Golgi membrane proteins. [provided by RefSeq, Jul 2008]

Function:
Activates HECT domain-containing E3 ubiquitin-protein ligases, including NEDD4 and ITCH, and consequently modulates the stability of their targets. As a result, controls many cellular processes. Prevents chronic T-helper cells-mediated inflammation by activating ITCH and thus controlling JUNB degradation (By similarity). In cortical neurons, mediates the ubiquitination of SLC11A2/DMT1 by NEDD4L, leading to down-regulation of the divalent metal transporter and protection of the cells from cobalt and iron toxicity. Modulates EGFR signaling through multiple pathways. In particular, may regulate the ratio of AKT1-to-MAPK8 signaling in response to EGF, acting on AKT1 probably through PTEN destabilization and on MAPK8 through ITCH-dependent MAP2K4 inactivation. As a result, may control cell growth rate.

Subunit:
Forms heterodimers with NDFIP2. Interacts with several E3 ubiquitin-protein ligases, including NEDD4, NEDD4L and WWP2. Interacts with ITCH, U2SURP and WWP2 By similarity. The interaction with NEDD4, NEDD4L and ITCH leads to relocalization of these proteins to exosomes and eventually to exosomal secretion. Interacts with SLC11A2/DMT1. Interacts with PTEN. May interact with phosphorylated EGFR.

Subcellular Location:
Endosome membrane. Golgi apparatus membrane. Secreted. Detected in exosomes and secreted via the exosomal pathway.

Tissue Specificity:
Widely expressed. Higher levels are detected in cerebellum, pituitary, thalamus, kidney, liver, testis, salivary glands and placenta. Also expressed in fetal brain, kidney and lung.

Post-translational modifications:
Ubiquitinated by NEDD4 and ITCH; mono-, di- and polyubiquitinated forms are detected. Ubiquitination regulates its degradation.
Undergoes transient tyrosine phosphorylation following EGF stimulation, most probably by catalyzed by SRC. Phosphorylation SRC is enhanced in the presence of NDFIP2 which may act as a scaffold to recruit SRC to NDFIP1.

Database links:

Entrez Gene: 80762 Human

Entrez Gene: 65113 Mouse

Entrez Gene: 291609 Rat

Omim: 612050 Human

SwissProt: Q9BT67 Human

SwissProt: Q8R0W6 Mouse

SwissProt: Q5U2S1 Rat

Unigene: 653510 Human

Unigene: 9788 Human

Unigene: 102496 Mouse

Unigene: 59254 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.ggggww.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 成年在线网站免费观看无广告 | 好吊色成人在线视频 | 亚洲精品在线免费看 | 黄色国产一级片 | 中文字幕永久 | 国产精品原创av片国产日韩 | 综合天天色 | 在线毛片网 | 国产综合视频在线观看 | xxxx国产精品 | 国产亚洲精选美女久久久久 | 国产情趣视频在线观看 | 99热国产在线中文 | 国精品人妻无码一区二区三区软件 | 成人性视频免费网站在线 | 亚洲自拍偷拍网站 | 中文字幕日本无码少妇 | 岛国无码免费不卡av | 欧美高潮失禁喷水呻吟日本视频 | 无遮无挡爽爽免费视频毛片韩国 | 四虎网站| 一边做一边喷17P亚洲乱妇50P | 人妻少妇精品视中文字幕国语 | 在线观看黄色免费 | 亚洲视频无码一区 | 好硬啊进得太深了A片无码公司 | 樱桃视频高清免费观看在线 | 国产亚洲精品久久久久久国模美 | 中文高清无码人妻 | 国产精选视频 | 曰韩内射六十七十老熟女影视 | 老司机亚洲精品一区二区 | 亚洲无亚洲人成网站77777 | 性荡视频播放在线视频7777 | mm1313亚洲国产精品美女 | 久久综合入口 | 国产高清在线观看av | 日本a在线播放 | 九九热在线免费观看 | 亚洲iv一区二区三区 | 特黄把女人弄爽a片 |