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Rabbit Anti-PRSS1/BF647 Conjugated antibody (bs-8744R-BF647)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-8744R-BF647
英文名稱 Rabbit Anti-PRSS1/BF647 Conjugated antibody
中文名稱 BF647標記的絲氨酸蛋白酶1抗體
別    名 Alpha trypsin chain 1; Alpha-trypsin chain 1; Alpha-trypsin chain 2; Beta-trypsin; Beta trypsin; Cationic trypsinogen; Serine protease 1; Serine protease-1; TRP1; TRY1; TRY1_HUMAN; TRYP1; Trypsin I; Trypsin-I; Trypsin 1; Trypsin-1.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  泛素  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Dog, )
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 27kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human PRSS1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is secreted by the pancreas and cleaved to its active form in the small intestine. It is active on peptide linkages involving the carboxyl group of lysine or arginine. Mutations in this gene are associated with hereditary pancreatitis. This gene and several other trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7. [provided by RefSeq, Jul 2008]

Function:
Has activity against the synthetic substrates Boc-Phe-Ser-Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val-Pro-Arg-Mec. The single-chain form is more active than the two-chain form against all of these substrates.

Subcellular Location:
Secreted > extracellular space.

Post-translational modifications:
Occurs in a single-chain form and a two-chain form, produced by proteolytic cleavage after Arg-122.

DISEASE:
Defects in PRSS1 are a cause of hereditary pancreatitis (HPC) [MIM:167800]; also known as chronic pancreatitis (CP). HPC is an autosomal dominant disease characterized by the presence of calculi in pancreatic ducts. It causes severe abdominal pain attacks.

Similarity:
Belongs to the peptidase S1 family.
Contains 1 peptidase S1 domain.

Database links:

Entrez Gene: 5644 Human

Entrez Gene: 114228 Mouse

Entrez Gene: 24691 Rat

Omim: 276000 Human

SwissProt: P00760 Cow

SwissProt: P07477 Human

SwissProt: P00762 Rat

Unigene: 449281 Human

Unigene: 449428 Mouse

Unigene: 34435 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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