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Rabbit Anti-SH3BP4/Cy5.5 Conjugated antibody (bs-19751R-Cy5.5)
訂購熱線:400-901-9800
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-19751R-Cy5.5
英文名稱 Rabbit Anti-SH3BP4/Cy5.5 Conjugated antibody
中文名稱 Cy5.5標記的SH3結構域結合蛋白4抗體
別    名 BOG25; EH binding protein; EH binding protein 10; EH-binding protein 10; EHB10; SH3 domain binding protein 4; SH3 domain-binding protein 4; SH3B4_HUMAN; sh3bp4; Transferrin receptor trafficking protein; Transferrin receptor-trafficking protein; TTP.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  信號轉導  轉運蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Mouse, Rat,  (predicted: Human, Cow, Horse, )
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 107kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human SH3BP4
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
This gene encodes a protein with 3 Asn-Pro-Phe (NPF) motifs, an SH3 domain, a PXXP motif, a bipartite nuclear targeting signal, and a tyrosine phosphorylation site. This protein is involved in cargo-specific control of clathrin-mediated endocytosis, specifically controlling the internalization of a specific protein receptor. [provided by RefSeq, Jul 2008]

Function:
Functions in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin-mediated endocytosis.

Subcellular Location:
Membrane > clathrin-coated pit. Cytoplasmic vesicle > clathrin-coated vesicle. Nucleus. Specifically associated with transferrin receptor-containing clathrin-coated pits and clathrin-coated vesicles. May also localize to the nucleus.

Tissue Specificity:
Expressed in all tissues tested with higher expression in pancreas. Expressed by retinal pigment epithelial cells (at protein level).

Post-translational modifications:
Phosphorylated upon EGF stimulation. Phosphorylation prevents interaction with DNM2.

Similarity:
Contains 1 SH3 domain.

Database links:

Entrez Gene: 520462 Cow

Entrez Gene: 486172 Dog

Entrez Gene: 100730563 Guinea pig

Entrez Gene: 100065797 Horse

Entrez Gene: 23677 Human

Entrez Gene: 98402 Mouse

Entrez Gene: 100347097 Rabbit

Entrez Gene: 64634 Rat

Omim: 605611 Human

SwissProt: Q9P0V3 Human

SwissProt: Q921I6 Mouse

SwissProt: Q9JJS5 Rat

Unigene: 516777 Human

Unigene: 170983 Mouse

Unigene: 35396 Rat

Unigene: 36062 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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