超碰97自拍_久久99久久98精品免观看软件_在线亚洲一区_九九视频这里只有精品_国产精品一区二区欧美视频_精品国产区一区

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
一区二区三区性视频,色综合久久88,久久国产影视
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-SATB1/Gold Conjugated antibody (bs-20148R-Gold)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價
產品編號 bs-20148R-Gold
英文名稱 Rabbit Anti-SATB1/Gold Conjugated antibody
中文名稱 膠體金標記的核基質結合區結合蛋白1抗體
別    名 DNA binding protein SATB1; DNA-binding protein SATB1; SATB homeobox 1; SATB1; SATB1_MOUSE; Special AT rich sequence binding protein 1 (binds to nuclear matrix/scaffold associating DNA); Special AT rich sequence binding protein 1; Special AT-rich sequence-binding protein 1.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul(10nm  15nm  35nm
研究領域 染色質和核信號  結合蛋白  新陳代謝  線粒體  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Mouse,  (predicted: Human, )
產品應用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 86kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human SATB1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產品介紹 background:
This gene encodes a matrix protein which binds nuclear matrix and scaffold-associating DNAs through a unique nuclear architecture. The protein recruits chromatin-remodeling factors in order to regulate chromatin structure and gene expression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]

Function:
Required for the switching of fetal globin species, and beta- and gamma-globin genes regulation during erythroid differentiation. Plays a role in chromatin organization and nuclear architecture during apoptosis (By similarity). Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma. Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Modulates genes that are essential in the maturation of the immune T-cell CD8SP from thymocytes.

Subunit:
Interacts with PCAF. Interacts with sumoylated PML and HDAC1 Tat via the PDZ-like dimerization domain. Interacts also with DYNLT3 and POLR2J2. Binds to EP300. Homodimer. Part of the nuclear protein complex gamma-globin promoter and enhancer binding factor (gamma-PE) composed at least by SATB1 and HOXB2. Interaction with CtBP1 when not acetylated stabalizes attachment to DNA and promotes transcription repression. Interacts (via DNA-binding domains) with CUX1; leading to inhibit the attachment to DNA.

Subcellular Location:
Nucleus. Nucleus, PML body. Note=Organized into a cage-like network anchoring loops of heterochromatin and tethering specialized DNA sequences. When sumoylated, localized in promyelocytic leukemia nuclear bodies (PML NBs).

Tissue Specificity:
Mainly expressed in thymus, spleen, and lymph nodes with a lower level observed in the brain.

Post-translational modifications:
Sumoylated. Sumoylation promotes cleavage by caspases.
Phosphorylated by PKC. Acetylated by PCAF. Phosphorylated form interacts with HDAC1, but unphosphorylated form interacts with PCAF. DNA binding properties are activated by phosphorylation and inactivated by acetylation. In opposition, gene expression is down-regulated by phosphorylation but up-regulated by acetylation.
Cleaved at Asp-254 by caspase-3 and caspase-6 during T-cell apoptosis in thymus and during B-cell stimulation. The cleaved forms can not dimerize and lose transcription regulation function because of impaired DNA and chromatin association.

Similarity:
Belongs to the CUT homeobox family.
Contains 2 CUT DNA-binding domains.
Contains 1 homeobox DNA-binding domain.

Database links:

Entrez Gene: 6304 Human

Entrez Gene: 20230 Mouse

Omim: 602075 Human

SwissProt: Q01826 Human

SwissProt: Q60611 Mouse

Unigene: 517717 Human

Unigene: 311655 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.ggggww.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: wc凹凸撒尿间谍女厕hd | 91年国产在线 | 成人精品av一区二区三区网站 | 3ce奇米四色眼影奇米8888 | 欧洲一卡2卡三卡4卡乱码毛1 | 西西大尺度美軳人人体av | 国产自慰网站在线观看 | 国产欧美日韩一区2区 | xxxxxhd亚洲人hd | 还珠格格第二部1至48集免费观看 | 91播放在线| 久久久久国产综合精品 | 国产精品国产三级国产AV中文 | 边摸边吃奶边做爽gif动态视频 | 成人午夜视频福利 | 伊人涩涩涩涩久久久AV | 天天骑天天干 | 黄在线观看网站 | 被黑人各种姿势猛烈进出视频 | 网站大全免费网址 | 国产一级片免费视频 | 亚洲av无一区二区三区 | 好紧好湿好黄的视频 | 国产在线高清视频无码不卡互動交流 | 狠狠插久久综合网最新章节 | 日韩人妻一区二区三区免费 | 久操av在线播放 | 中文字幕人妻在线中文乱码怎么解决 | chinese国产高清av内谢 | 免费国产高清在线精品一区 | 一二三四区在线视频 | 九一自拍中文字幕 | 国产精自产拍久久久久久蜜 | www.77伦理bt.com| 日本护士野外奶水HD | 国产偷抇久久精品 | 满天神佛国语免费观看 | 国产女厕偷窥系列在线视频 | 午夜精品久久久久久久99 | 狂猛欧美激情性XXXX大豆行情 | 青草网址|