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Rabbit Anti-phospho-PLB(Ser16+Thr17)/BF350 Conjugated antibody (bs-10999R-BF350)
訂購熱線:400-901-9800
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-10999R-BF350
英文名稱 Rabbit Anti-phospho-PLB(Ser16+Thr17)/BF350 Conjugated antibody
中文名稱 BF350標記的磷酸化心臟磷蛋白(Ser16+Thr17)抗體
別    名 Phospholamban (phospho S16+T17); p-Phospholamban (phospho S16+T17); Phospho-Phospholamban (Ser16/Thr17); phospholamban(phospho Ser16+Thr17); p-PLB(S16+T17); Cardiac phospholamban; CMD1P; PLB; PLN; PPLA_HUMAN.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 心血管  免疫學  信號轉導  轉錄調節因子  通道蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 6kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human phospho-PLB(Ser16+Thr17)
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure. [provided by RefSeq, Jul 2008].

Function:
Phospholamban has been postulated to regulate the activity of the calcium pump of cardiac sarcoplasmic reticulum.

Subunit:
Homopentamer. Interacts with HAX1.

Subcellular Location:
Mitochondrion membrane. Sarcoplasmic reticulum.

Tissue Specificity:
Heart.

Post-translational modifications:
Phosphorylated at Thr-17 by CaMK2, and in response to beta-adrenergic stimulation. Phosphorylation by DMPK may stimulate sarcoplasmic reticulum calcium uptake in cardiomyocytes.

DISEASE:
Defects in PLN are the cause of cardiomyopathy dilated type 1P (CMD1P) [MIM:609909]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. Defects in PLN are the cause of cardiomyopathy familial hypertrophic type 18 (CMH18) [MIM:613874]. CMH18 is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.

Similarity:
Belongs to the phospholamban family.

Database links:

Entrez Gene: 5350 Human

Entrez Gene: 18821 Mouse

Entrez Gene: 64672 Rat

Omim: 172405 Human

SwissProt: P26677 Chicken

SwissProt: A4IFH6 Cow

SwissProt: P61012 Dog

SwissProt: P26678 Human

SwissProt: P61014 Mouse

SwissProt: P61013 Pig

SwissProt: P61015 Rabbit

SwissProt: P61016 Rat

Unigene: 170839 Human

Unigene: 34145 Mouse

Unigene: 9740 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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