超碰97自拍_久久99久久98精品免观看软件_在线亚洲一区_九九视频这里只有精品_国产精品一区二区欧美视频_精品国产区一区

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
国产免费传媒av片生线,爱爱爱av,亚洲AV无码日韩AV无码网址
首頁 > 產品中心 > 標記一抗 > 產品信息
Mouse Anti-SGK1/RBITC Conjugated antibody (bsm-33275M-RBITC)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bsm-33275M-RBITC
英文名稱 Mouse Anti-SGK1/RBITC Conjugated antibody
中文名稱 羅丹明(RBITC)標記的糖皮質激素調節激酶1單克隆抗體
別    名 Serum/glucocorticoid regulated kinase 1; SGK 1; SGK-1; Serine/threonine protein kinase SGK; Serine/threonine protein kinase Sgk1; Serum and glucocorticoid regulated kinase; Serum/glucocorticoid regulated kinase; SGK 1; SGK; SGK1_HUMAN.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  細胞生物  免疫學  信號轉導  生長因子和激素  轉錄調節因子  激酶和磷酸酶  
抗體來源 Mouse
克隆類型 Monoclonal
克 隆 號 5E11
交叉反應 Mouse,  (predicted: Human, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 49kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human SGK1
亞    型 IgG
純化方法 affinity purified by Protein G
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
SGK1 is a protein kinase that plays an important role in cellular stress response. SGK1 activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. Sustained high levels of SGK1 and activity may contribute to conditions such as hypertension and diabetic nephropathy. This protein also mediates cell survival signals, as it has been shown to phosphorylate and negatively regulate the pro apoptotic FOXO3A protein. Ser 422 is a critical site on the protein and may be involved in its activation.

Function:
Protein kinase that plays an important role in cellular stress response. Activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability and renal sodium excretion. Sustained high levels and activity may contribute to conditions such as hypertension and diabetic nephropathy. Mediates cell survival signals, phosphorylates and negatively regulates pro-apoptotic FOXO3A. Phosphorylates NEDD4L, which leads to its inactivation and to the subsequent activation of various channels and transporters such as ENaC, KCNA3/Kv1.3 or EAAT1. Isoform 2 exhibited a greater effect on cell plasma membrane expression of ENaC and Na(+) transport than isoform 1.

Subunit:
Homodimer; disulfide-linked. Forms a trimeric complex with FBXW7 and NOTCH1. Interacts with MAPK3/ERK1, MAPK1/ERK2, MAP2K1/MEK1, MAP2K2/MEK2, NEDD4, NEDD4L, MAPT/TAU, MAPK7, CREB1, SLC9A3R2/NHERF2 and KCNJ1/ROMK1. Associates with the mammalian target of rapamycin complex 2 (mTORC2) via an interaction with MAPKAP1/SIN1.

Subcellular Location:
Cell membrane and Cytoplasm. Nucleus. Endoplasmic reticulum. Nuclear, upon phosphorylation.

Tissue Specificity:
Expressed in most tissues with highest levels in the pancreas, followed by placenta, kidney and lung. Isoform 2 is strongly expressed in brain and pancreas, weaker in heart, placenta, lung, liver and skeletal muscle.

Post-translational modifications:
Regulated by phosphorylation. Phosphoinositide 3-kinase (PI3-kinase) pathway promotes phosphorylation at Ser-422 which in turn increases the phosphorylation of Thr-256 by PDPK1.
Ubiquitinated by NEDD4L; which promotes proteasomal degradation. Ubiquitinated by SYVN1 at the endoplasmic reticulum; which promotes rapid proteasomal degradation and maintains a high turnover rate in resting cells. Isoform 2 shows enhanced stability. Isoform 2 resistance to proteasomal degradation is mediated by the sequences within the first 120-amino acid.

Similarity:
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
Contains 1 AGC-kinase C-terminal domain.
Contains 1 protein kinase domain.

Database links:

Entrez Gene: 6446 Human

Entrez Gene: 20393 Mouse

Entrez Gene: 29517 Rat

Omim: 602958 Human

SwissProt: O00141 Human

SwissProt: Q9WVC6 Mouse

SwissProt: Q06226 Rat

Unigene: 510078 Human

Unigene: 28405 Mouse

Unigene: 4636 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.ggggww.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 亚洲地区天堂网 | 午夜国产福利在线 | jizz大全日本护士喷奶水 | 亚洲欧洲天堂 | 无码AV中文一二三区 | 亚州av网| 国产在线观看xxx | 国产高清学生妹在线观看视频一区 | 国产成人精品久久一区二区三区 | 91首页 | 国产理论在线播放 | 91老司机福利在线 | 日本地区不卡一区二区三区搜索 | 琪琪成人影视啪啪成人片 | 黑人巨大无码中文字幕无码 | 无码人妻精品一区二秋霞影院 | 人妻内射视频麻豆 | 日韩精品一区二区三区在线 | 亚洲天堂导航 | 日韩第一页在线观看 | 拔插拔插在线观看 | 国产玉足榨精视频在线 | 欧美日韩一区二区在线视频播放 | 中国老太老妇xx对白 | 香港经典av三级观看 | 日韩中文字幕一区二区高清99 | 簧片免费网站 | 国产高清在线精品一本大道 | 中文字幕无码精品亚洲资源网久久 | 亚洲自拍偷拍网站 | 久久精品国产99国产精品亚洲 | 中文字幕ˉ色哟哟 | av解说在线精品 | 色屁屁WWW免费看欧美激情 | 国产精品性爱亚洲av性爱 | 91高清在线免费观看 | 亚洲国产中文精品综合久久 | 特级毛片AAAAAA | 亚洲高清国产拍精品影院 | 亚洲精品久久久久久久久久吃药 | 国产女人高潮叫床免费视频 |