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Rabbit Anti-CRF/Biotin Conjugated antibody (bs-41044R-Bio)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-41044R-Bio
英文名稱 Rabbit Anti-CRF/Biotin Conjugated antibody
中文名稱 生物素標記的促腎上腺皮質激素釋放因子/促腎上皮質激素釋放激素抗體
別    名 Corticoliberin; Corticoliberin precursor; Corticotropin releasing factor; Corticotropin releasing hormone; Corticotropin releasing hormone deficiency included; crf; crh; crh deficiency included; corticoliberin preproprotein; CRF_HUMAN; Corticotropin-releasing factor; CRH1; CRH; Corticotropin-releasing hormone.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 神經生物學  內分泌病  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Mouse, Rat,  (predicted: Human, Dog, Pig, Rabbit, Guinea Pig, )
產品應用 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 5/22kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CRF
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
This gene encodes a member of the corticotropin-releasing factor family. The encoded preproprotein is proteolytically processed to generate the mature neuropeptide hormone. In response to stress, this hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus, binds to corticotropin releasing hormone receptors and stimulates the release of adrenocorticotropic hormone from the pituitary gland. Marked reduction in this protein has been observed in association with Alzheimer's disease. Autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes, and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this protein may act as a trigger for parturition. [provided by RefSeq, Nov 2015]

Function:
This hormone from hypothalamus regulates the release of corticotropin from pituitary gland.

Subunit:
Interacts (via C-terminus) with CRFR1 (via N-terminalv extracellular domain).

Subcellular Location:
Secreted.

Similarity:
Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.

Database links:

Entrez Gene: 1392 Human

Entrez Gene: 12918 Mouse

Entrez Gene: 81648 Rat

Omim: 122560 Human

SwissProt: P06850 Human

SwissProt: Q8CIT0 Mouse

SwissProt: P01143 Rat

Unigene: 75294 Human

Unigene: 290689 Mouse

Unigene: 10349 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

CRF陽性神經元的胞體廣泛分布于下丘腦的室旁核、背縫核和藍斑核,這些區域也是去甲腎上腺素(NE)神經元與5-羥色胺(5-HT)神經元密集的區域。
CRF既具有神經遞質的性質又具有神經激素的性質。CRF是聯系神經系統與內分泌系統的橋梁,在情感障礙疾患如焦慮和抑郁的發病中發揮重要作用.
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