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Mouse Anti-Gamma Tubulin/Gold Conjugated antibody (bsm-33313M-Gold)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價
產品編號 bsm-33313M-Gold
英文名稱 Mouse Anti-Gamma Tubulin/Gold Conjugated antibody
中文名稱 膠體金標記的微管蛋白γ單克隆抗體
別    名 Centrosome Marker; Gamma 1 tubulin; gamma tubulin; gamma-tubulin; Gamma 2 tubulin; Gamma Tubulin 1; Gamma Tubulin 2; Gamma tubulin complex component 1; GCP 1; GCP-1; GCP1; MGC131994; TUBG; TUBG1; TUBG2; Tubulin gamma 1 chain; Tubulin gamma 2 chain; Xgam; TBG1_HUMAN; TBG2_HUMAN; Tubulin gamma-1 chain; Gamma-1-tubulin; Gamma-tubulin complex component 1.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul(10nm  15nm  35nm
產品類型 內參抗體 
研究領域 細胞生物  神經生物學  細胞骨架  
抗體來源 Mouse
克隆類型 Monoclonal
克 隆 號 8D11
交叉反應 Mouse, Rat,  (predicted: Human, )
產品應用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 50kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Gamma Tubulin
亞    型 IgG
純化方法 affinity purified by Protein G
儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產品介紹 background:
Centrosome Marker
Gamma tubulin, a member of the tubulin superfamily, is a ubiquitous and highly conserved protein within the microtubule organizing centre (MTOC). Gamma tubulin is not a component of microtubules, rather it functions as the microtubule nucleator at the MOTC, is responsible for binding microtubule minus ends and mediating the link between microtubles and the centrosome. By binding to the beta tubulin subunit of the tubulin molecule, it establishes the polarity of a microtubule leaving the alpha tubulin subunit exposed at the positive end.
The abundance of Gamma tubulin is less than 1% of the level of either alpha or beta tubulin. It shares approximately 28-32% identity with alpha tubulin from various organisms and 32-36% identity with beta tubulins. The detection, localization and characterization of proteins involved in microtubule function is fundamental to the understanding of mitosis, meiosis and the microtubule cytoskeleton.

Function:
Tubulin is the major constituent of microtubules. Gamma tubulin is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta tubulin minus-end nucleation, centrosome duplication and spindle formation.

Subunit:
Interacts with TUBGCP2 and TUBGCP3. Interacts with B9D2 (By similarity). Interacts with CDK5RAP2; the interaction is leading to centrosomal localization of TUBG1 and CDK5RAP2. Interacts with PIFO.

Subcellular Location:
Cytoplasm, cytoskeleton, centrosome.

Tissue Specificity:
Phosphorylation at Ser-131 by BRSK1 regulates centrosome duplication, possibly by mediating relocation of gamma-tubulin and its associated proteins from the cytoplasm to the centrosome.

Post-translational modifications:
Phosphorylation at Ser-131 by BRSK1 regulates centrosome duplication, possibly by mediating relocation of gamma-tubulin and its associated proteins from the cytoplasm to the centrosome.

Similarity:
Belongs to the tubulin family.

Database links:

Entrez Gene: 27175 Human

Entrez Gene: 7283 Human

Entrez Gene: 103733 Mouse

Entrez Gene: 103768 Mouse

Entrez Gene: 252921 Rat

Entrez Gene: 680991 Rat

Omim: 191135 Human

Omim: 605785 Human

SwissProt: P23258 Human

SwissProt: Q9NRH3 Human

SwissProt: P83887 Mouse

SwissProt: Q8VCK3 Mouse

SwissProt: P83888 Rat

Unigene: 279669 Human

Unigene: 708059 Human

Unigene: 142348 Mouse

Unigene: 479145 Mouse

Unigene: 154431 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

結構蛋白(Structural Proteins)
gamma tubulin 微管蛋白是存于中心體的另一種微管蛋白, gamma微管蛋白對微管的形成具有重要作用。gamma微管蛋白通過與β-微管蛋白的相互作用幫助微管的成核反應(nucleation)。即在微管的組裝中gamma微管蛋白先形成一個圓或形成鉤環結構, γ微管蛋白的這種結構可指導微管蛋白二聚體結合上去并進行微管的組裝。gamma微管蛋白在微管的組裝中起關鍵作用。
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