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Mouse Anti-GRP78/Bip/Biotin Conjugated antibody (bsm-33224M-Bio)
訂購熱線:400-901-9800
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bsm-33224M-Bio
英文名稱 Mouse Anti-GRP78/Bip/Biotin Conjugated antibody
中文名稱 生物素標記的葡萄糖調節蛋白78單克隆抗體
別    名 BIP; HSPA5; glucose regulated protein 78; 78 kDa glucose regulated protein; BIP; Endoplasmic reticulum lumenal Ca2+ binding protein grp78; FLJ26106; Glucose Regulated Protein 78kDa; GRP 78; GRP78; Heat Shock 70kDa Protein 5; HSPA 5; HSPA-5; HSPA5; Immunoglobulin Heavy Chain Binding Protein; MIF2; GRP78_HUMAN.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  細胞生物  免疫學  
抗體來源 Mouse
克隆類型 Monoclonal
克 隆 號 10A3
交叉反應 Human,  (predicted: Rat, )
產品應用 WB=1:50-200 IHC-F=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 78kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human GRP78/Bip
亞    型 IgG
純化方法 affinity purified by Protein G
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
The 78 kDa glucose regulated protein/BiP (GRP78) belongs to the family of ~70 kDa heat shock proteins (HSP 70). GRP78 is a resident protein of the endoplasmic reticulum (ER) and may associate transiently with a variety of newly synthesized secretory and membrane proteins or permanently with mutant or defective proteins that are incorrectly folded, thus preventing their export from the ER lumen. GRP78 is a highly conserved protein that is essential for cell viability. The highly conserved sequence Lys-Asp-Glu-Leu (KDEL) is present at the C terminus of GRP78 and other resident ER proteins including glucose regulated protein 94 (GRP 94) and protein disulfide isomerase (PDI). The presence of carboxy terminal KDEL appears to be necessary for retention and appears to be sufficient to reduce the secretion of proteins from the ER. This retention is reported to be mediated by a KDEL receptor.

Function:
Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.

Subcellular Location:
Endoplasmic reticulum lumen. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

DISEASE:
Note=Autoantigen in rheumatoid arthritis.

Similarity:
Belongs to the heat shock protein 70 family.

Database links:

Entrez Gene: 3309 Human

Entrez Gene: 14828 Mouse

Entrez Gene: 25617 Rat

Omim: 138120 Human

SwissProt: P11021 Human

SwissProt: P20029 Mouse

SwissProt: P06761 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

葡萄糖調節蛋白78是熱休克蛋白70家族的成員之一又稱:熱休克蛋白70蛋白5,作為一種分子伴侶在蛋白質的折疊和轉運過程及內質網應激反應中發揮重要作用.它在多種腫瘤組織中呈高表達.
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