超碰97自拍_久久99久久98精品免观看软件_在线亚洲一区_九九视频这里只有精品_国产精品一区二区欧美视频_精品国产区一区

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
大学生不戴套毛片视频,日本国产精品无码字幕在线观看,美腿制服丝袜国产亚洲
首頁 > 產品中心 > 標記一抗 > 產品信息
Mouse Anti-PARP/Cy7 Conjugated antibody (bsm-33137M-Cy7)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bsm-33137M-Cy7
英文名稱 Mouse Anti-PARP/Cy7 Conjugated antibody
中文名稱 Cy7標記的多腺苷二磷酸多聚酶/多聚ADP-核糖聚合酶1單克隆抗體
別    名 ADP ribosyltransferase (NAD+; poly (ADP ribose) polymerase); ADP ribosyltransferase NAD+; ADPRT 1; ADPRT; ADPRT1; msPARP; NAD(+) ADP ribosyltransferase 1; pADPRT 1; pADPRT1; PARP 1; PARP1; PARP-1; Poly (ADP ribose) polymerase 1; poly (ADP ribose) polymerase family, member 1; Poly adenosine diphosphate ADP ribose polymerase; Poly ADP ribose polymerase 1; Poly ADP ribose polymerase family member 1; Poly ADP ribose synthetase 1; poly(ADP ribose) synthetase; poly(ADP ribosyl)transferase; Poly[ADP ribose] synthetase 1; PPOL; sPARP 1; sPARP1; PARP1_HUMAN.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  心血管  細胞生物  信號轉導  細胞凋亡  新陳代謝  線粒體  
抗體來源 Mouse
克隆類型 Monoclonal
克 隆 號 5B7
交叉反應 (predicted: Human, )
產品應用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 116kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human PARP
亞    型 IgG
純化方法 affinity purified by Protein G
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [provided by RefSeq, Jul 2008].

Function:
Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.

Subunit:
Component of a base excision repair (BER) complex, containing at least XRCC1, PARP2, POLB and LRIG3. Homo- and heterodimer with PARP2. Interacts with PARP3, APTX and SRY. The SWAP complex consists of NPM1, NCL, PARP1 and SWAP70. Interacts with TIAM2 and ZNF423 (By similarity). Interacts (when poly-ADP-ribosylated) with CHD1L. Interacts with the DNA polymerase alpha catalytic subunit POLA1; this interaction functions as part of the control of replication fork progression. Interacts with EEF1A1, RNF4 and TXK.

Subcellular Location:
Mitochondrion outer membrane; Single-pass membrane protein.
Nucleus membrane; Single-pass membrane protein.
Endoplasmic reticulum membrane; Single-pass membrane protein.
Nucleus.

Post-translational modifications:
Phosphorylated by PRKDC and TXK. Phosphorylated upon DNA damage, probably by ATM or ATR.
Poly-ADP-ribosylated by PARP2. Poly-ADP-ribosylation mediates the recruitment of CHD1L to DNA damage sites.
S-nitrosylated, leading to inhibit transcription regulation activity.

Similarity:
Contains 1 BRCT domain.
Contains 1 PARP alpha-helical domain.
Contains 1 PARP catalytic domain.
Contains 2 PARP-type zinc fingers.

Database links:

Entrez Gene: 142 Human

Entrez Gene: 11545 Mouse

Entrez Gene: 25591 Rat

Omim: 173870 Human

SwissProt: P09874 Human

SwissProt: P11103 Mouse

SwissProt: P27008 Rat

Unigene: 177766 Human

Unigene: 277779 Mouse

Unigene: 11327 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.ggggww.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 大陆国产乱人伦 | 麻豆国产在线播放 | 一区二区三区在线观看欧美 | 国产一区日韩 | 免费人成网站www | 蜜桃视频成人在线观看 | 成人国产网站 | 日韩天堂网 | 久久久午夜精品福利内容 | 国产超碰人人做人人爱 | 久久久久久女乱国产 | 国产在线精品一区二区中文 | 精品视频一区二区三区 | 一级毛片子 | 香港aa三级久久三级 | 99热这里只有精品9988 | 无码熟妇人妻AV在线影片最多 | 男女视频一区二区 | 精品人伦一区二区三区蜜桃免费 | 日日噜噜噜夜夜爽爽狠狠小说 | 亚洲一区在线免费 | 免费精品国偷自产在线青年 | 久久一久久| 人妻少妇精品视中文字幕国语 | 久久久久久久久免费视频 | 久久精品国产2019国产精品 | 日本少妇ⅹxxhd第一次 | 久草婷婷| 精品久久久久久无码 | 久久国产一级片 | 91中文啦| 午夜成人免费影院 | 很黄很爽的视频网站 | 一级片国产片 | 国产做a爱一级久久 | 午在线亚洲男人午在线 | 两个人免费视频www 国产精品偷窥熟女精品视频 | 欧美丰满熟妇乱XXXXX图片 | 麻豆精品一二三区 | 亚洲AV永久无码3D动漫在线观看 | 高潮流白浆潮喷在线播放视频 |